L5147

Sigma

 

Lectin from Artocarpus integrifolia

agarose conjugate, saline suspension

Synonym:Artocarpus integrifolia agglutinin, Jacalin
MDL number:MFCD00162973

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Description

ApplicationUsed for the purification of glycoproteins containing α-D-galactose
Biochem/physiol ActionsJacalin is extracted from Jack fruit seeds; a glycoprotein reported to bind human serum and secretory IgA.1 Jacalin is not blood group specific.2 The most effective inhibitor of hemagglutination is methyl α-D-galactopyranoside. The lectin is specific toward the Thomsen-Friedenreich (T) antigen, but has subtle differences in its combining site when compared to the site of Arachis hypogaea (peanut) agglutinin.3 Jacalin was also demonstrated to be a mitogen of T-lymphocytes.1
Physical formSuspension in 1 M NaCl containing 0.01% thimerosal

Properties

formsaline suspension
extent of labeling~5 mg per mL
matrix cross-linked 4% beaded agarose
capacity 1-2 mg/mL binding capacity (human IgA)
conjugateagarose conjugate
storage temp.2-8°C

Safety

Safety Statements22-24/25

References

Cited Reference1. Sastry, M. V., Analysis of saccharide binding to Artocarpus integrifolia lectin reveals specific recognition of T-antigen (β-D-Gal-(1→3)-D-GalNAc). J. Biol. Chem. 261, 11726, (1986)
 2. Roque-Barreira, M.C., Campos-Neto, A., Jacalin: An IgA-binding Lectin. J. Immunol. 134, 1740, (1985)
 3. Ahmed, H., Chatterjee, B.P. J. Immunol. Berlin 5, 125, (1986)